Bone Morphogenic Protein (BMP) Signaling Up-regulates Neutral Sphingomyelinase 2 to Suppress Chondrocyte Maturation via the Akt Protein Signaling Pathway as a Negative Feedback Mechanism

Although bone morphogenic protein (BMP) signaling promotes chondrogenesis, it is not clear whether BMP-induced chondrocyte maturation is cell-autonomously terminated. Loss of function of Smpd3 in mice results in an increase in mature hypertrophic chondrocytes. Here, we report that in chondrocytes th...

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Dades bibliogràfiques
Autors principals: Kakoi, Hironori, Maeda, Shingo, Shinohara, Naohiro, Matsuyama, Kanehiro, Imamura, Katsuyuki, Kawamura, Ichiro, Nagano, Satoshi, Setoguchi, Takao, Yokouchi, Masahiro, Ishidou, Yasuhiro, Komiya, Setsuro
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2014
Matèries:
Cell Biology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3961644/
https://ncbi.nlm.nih.gov/pubmed/24505141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.509331
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