Bone Morphogenic Protein (BMP) Signaling Up-regulates Neutral Sphingomyelinase 2 to Suppress Chondrocyte Maturation via the Akt Protein Signaling Pathway as a Negative Feedback Mechanism

Although bone morphogenic protein (BMP) signaling promotes chondrogenesis, it is not clear whether BMP-induced chondrocyte maturation is cell-autonomously terminated. Loss of function of Smpd3 in mice results in an increase in mature hypertrophic chondrocytes. Here, we report that in chondrocytes th...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Kakoi, Hironori, Maeda, Shingo, Shinohara, Naohiro, Matsuyama, Kanehiro, Imamura, Katsuyuki, Kawamura, Ichiro, Nagano, Satoshi, Setoguchi, Takao, Yokouchi, Masahiro, Ishidou, Yasuhiro, Komiya, Setsuro
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3961644/
https://ncbi.nlm.nih.gov/pubmed/24505141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.509331
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados