Allele-Specific Knockdown of ALS-Associated Mutant TDP-43 in Neural Stem Cells Derived from Induced Pluripotent Stem Cells

TDP-43 is found in cytoplasmic inclusions in 95% of amyotrophic lateral sclerosis (ALS) and 60% of frontotemporal lobar degeneration (FTLD). Approximately 4% of familial ALS is caused by mutations in TDP-43. The majority of these mutations are found in the glycine-rich domain, including the variant...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Nishimura, Agnes L., Shum, Carole, Scotter, Emma L., Abdelgany, Amr, Sardone, Valentina, Wright, Jamie, Lee, Youn-Bok, Chen, Han-Jou, Bilican, Bilada, Carrasco, Monica, Maniatis, Tom, Chandran, Siddharthan, Rogelj, Boris, Gallo, Jean-Marc, Shaw, Christopher E.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Public Library of Science 2014
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3961241/
https://ncbi.nlm.nih.gov/pubmed/24651281
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0091269
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg