Astrocyte pathology and the absence of non-cell autonomy in an induced pluripotent stem cell model of TDP-43 proteinopathy

Glial proliferation and activation are associated with disease progression in amyotrophic lateral sclerosis (ALS) and frontotemporal lobar dementia. In this study, we describe a unique platform to address the question of cell autonomy in transactive response DNA-binding protein (TDP-43) proteinopath...

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Detalhes bibliográficos
Main Authors: Serio, Andrea, Bilican, Bilada, Barmada, Sami J., Ando, Dale Michael, Zhao, Chen, Siller, Rick, Burr, Karen, Haghi, Ghazal, Story, David, Nishimura, Agnes Lumi, Carrasco, Monica A., Phatnani, Hemali P., Shum, Carole, Wilmut, Ian, Maniatis, Tom, Shaw, Christopher E., Finkbeiner, Steven, Chandran, Siddharthan
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2013
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3607024/
https://ncbi.nlm.nih.gov/pubmed/23401527
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1300398110
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