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RGS4 regulates partial agonism of the M2 muscarinic receptor-activated K(+) currents
Partial agonists are used clinically to avoid overstimulation of receptor-mediated signalling, as they produce a submaximal response even at 100% receptor occupancy. The submaximal efficacy of partial agonists is due to conformational change of the agonist–receptor complex, which reduces effector ac...
Shranjeno v:
| Main Authors: | , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Blackwell publishing Ltd
2014
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3961084/ https://ncbi.nlm.nih.gov/pubmed/24421355 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2013.269803 |
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