The dsRBP and inactive editor, ADR-1, utilizes dsRNA binding to regulate A-to-I RNA editing across the C. elegans transcriptome

Inadequate adenosine-to-inosine editing of noncoding regions occurs in disease, often uncorrelated with ADAR levels, underscoring the need to study deaminase-independent control of editing. C. elegans have two ADAR proteins, ADR-2 and the theoretically catalytically inactive ADR-1. Using high-throug...

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Main Authors: Washburn, Michael C., Kakaradov, Boyko, Sundararaman, Balaji, Wheeler, Emily, Hoon, Shawn, Yeo, Gene W., Hundley, Heather A.
Formato: Artigo
Idioma:Inglês
Publicado: 2014
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3959997/
https://ncbi.nlm.nih.gov/pubmed/24508457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2014.01.011
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