Inhibition of keratinocyte proliferation by phospholipid-conjugates of a TLR7 ligand in a Myc-induced hyperplastic actinic keratosis model in the absence of systemic side effects

BACKGROUND: The Toll-like receptor 7 (TLR7) activator imiquimod (IMQ) is safe and effective in treating actinic keratosis; however, an intermittent treatment regimen is necessary because of excessive local reactions. OBJECTIVES: To evaluate in vitro potency, pharmacodynamics/pharmacokinetics, toxici...

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Detalhes bibliográficos
Main Authors: CRAIN, Brian, YAO, Shiyin, KEOPHILAONE, Vina, PROMESSI, Victor, KANG, McNancy, BARBERIS, Alcide, MAJ, Roberto, MURA, Emanuela, PASSINI, Nadia, HOLLDACK, Johanna, OCHOA, Ricardo, COTTAM, Howard B., CARSON, Dennis A., HAYASHI, Tomoko
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3959874/
https://ncbi.nlm.nih.gov/pubmed/24225049
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1684/ejd.2013.2155
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