Functional interaction of Parkinson's disease-associated LRRK2 with members of the dynamin GTPase superfamily

Mutations in LRRK2 cause autosomal dominant Parkinson's disease (PD). LRRK2 encodes a multi-domain protein containing GTPase and kinase domains, and putative protein–protein interaction domains. Familial PD mutations alter the GTPase and kinase activity of LRRK2 in vitro. LRRK2 is suggested to...

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Bibliographic Details
Main Authors: Stafa, Klodjan, Tsika, Elpida, Moser, Roger, Musso, Alessandra, Glauser, Liliane, Jones, Amy, Biskup, Saskia, Xiong, Yulan, Bandopadhyay, Rina, Dawson, Valina L., Dawson, Ted M., Moore, Darren J.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2014
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3959816/
https://ncbi.nlm.nih.gov/pubmed/24282027
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddt600
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