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IL‐6 Regulates Extracellular Matrix Remodeling Associated With Aortic Dilation in a Fibrillin‐1 Hypomorphic mgR/mgR Mouse Model of Severe Marfan Syndrome

BACKGROUND: Development of thoracic aortic aneurysms is the most significant clinical phenotype in patients with Marfan syndrome. An inflammatory response has been described in advanced stages of the disease. Because the hallmark of vascular inflammation is local interleukin‐6 (IL‐6) secretion, we e...

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Dettagli Bibliografici
Autori principali: Ju, Xiaoxi, Ijaz, Talha, Sun, Hong, LeJeune, Wanda, Vargas, Gracie, Shilagard, Tuya, Recinos, Adrian, Milewicz, Dianna M., Brasier, Allan R., Tilton, Ronald G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Blackwell Publishing Ltd 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3959679/
https://ncbi.nlm.nih.gov/pubmed/24449804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.113.000476
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