IL‐6 Regulates Extracellular Matrix Remodeling Associated With Aortic Dilation in a Fibrillin‐1 Hypomorphic mgR/mgR Mouse Model of Severe Marfan Syndrome

BACKGROUND: Development of thoracic aortic aneurysms is the most significant clinical phenotype in patients with Marfan syndrome. An inflammatory response has been described in advanced stages of the disease. Because the hallmark of vascular inflammation is local interleukin‐6 (IL‐6) secretion, we e...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Ju, Xiaoxi, Ijaz, Talha, Sun, Hong, LeJeune, Wanda, Vargas, Gracie, Shilagard, Tuya, Recinos, Adrian, Milewicz, Dianna M., Brasier, Allan R., Tilton, Ronald G.
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2014
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3959679/
https://ncbi.nlm.nih.gov/pubmed/24449804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.113.000476
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados