IL‐6 Regulates Extracellular Matrix Remodeling Associated With Aortic Dilation in a Fibrillin‐1 Hypomorphic mgR/mgR Mouse Model of Severe Marfan Syndrome

BACKGROUND: Development of thoracic aortic aneurysms is the most significant clinical phenotype in patients with Marfan syndrome. An inflammatory response has been described in advanced stages of the disease. Because the hallmark of vascular inflammation is local interleukin‐6 (IL‐6) secretion, we e...

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Bibliographic Details
Main Authors: Ju, Xiaoxi, Ijaz, Talha, Sun, Hong, LeJeune, Wanda, Vargas, Gracie, Shilagard, Tuya, Recinos, Adrian, Milewicz, Dianna M., Brasier, Allan R., Tilton, Ronald G.
Format: Artigo
Language:Inglês
Published: Blackwell Publishing Ltd 2014
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Original Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3959679/
https://ncbi.nlm.nih.gov/pubmed/24449804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.113.000476
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