Loss of Endothelial Barrier in Marfan Mice (mgR/mgR) Results in Severe Inflammation after Adenoviral Gene Therapy

OBJECTIVES: Marfan syndrome is an autosomal dominant inherited disorder of connective tissue. The vascular complications of Marfan syndrome have the biggest impact on life expectancy. The aorta of Marfan patients reveals degradation of elastin layers caused by increased proteolytic activity of matri...

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Pubblicato in:PLoS One
Autori principali: Seppelt, Philipp Christian, Schwill, Simon, Weymann, Alexander, Arif, Rawa, Weber, Antje, Zaradzki, Marcin, Richter, Karsten, Ensminger, Stephan, Robinson, Peter Nicholas, Wagner, Andreas H., Karck, Matthias, Kallenbach, Klaus
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2016
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4740453/
https://ncbi.nlm.nih.gov/pubmed/26840980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0148012
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