Loss of Endothelial Barrier in Marfan Mice (mgR/mgR) Results in Severe Inflammation after Adenoviral Gene Therapy

OBJECTIVES: Marfan syndrome is an autosomal dominant inherited disorder of connective tissue. The vascular complications of Marfan syndrome have the biggest impact on life expectancy. The aorta of Marfan patients reveals degradation of elastin layers caused by increased proteolytic activity of matri...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Seppelt, Philipp Christian, Schwill, Simon, Weymann, Alexander, Arif, Rawa, Weber, Antje, Zaradzki, Marcin, Richter, Karsten, Ensminger, Stephan, Robinson, Peter Nicholas, Wagner, Andreas H., Karck, Matthias, Kallenbach, Klaus
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4740453/
https://ncbi.nlm.nih.gov/pubmed/26840980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0148012
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