Spliced X-box Binding Protein 1 Couples the Unfolded Protein Response to Hexosamine Biosynthetic Pathway

The hexosamine biosynthetic pathway (HBP) generates UDP-GlcNAc (uridine diphosphate N-acetylglucosamine) for glycan synthesis and O-linked GlcNAc (O-GlcNAc) protein modifications. Despite the established role of the HBP in metabolism and multiple diseases, regulation of the HBP remains largely undef...

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Autori principali: Wang, Zhao V., Deng, Yingfeng, Gao, Ningguo, Pedrozo, Zully, Li, Dan L., Morales, Cyndi R., Criollo, Alfredo, Luo, Xiang, Tan, Wei, Jiang, Nan, Lehrman, Mark A., Rothermel, Beverly A., Lee, Ann-Hwee, Lavandero, Sergio, Mammen, Pradeep P.A., Ferdous, Anwarul, Gillette, Thomas G., Scherer, Philipp E., Hill, Joseph A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3959665/
https://ncbi.nlm.nih.gov/pubmed/24630721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2014.01.014
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