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Fluoxetine and norfluoxetine stereospecifically facilitate pentobarbital sedation by increasing neurosteroids

Mice housed in social isolation exhibit a decreased response to γ-aminobutyric acid-mimetic drugs [i.e., pentobarbital (PTB)] associated with a down-regulation of telencephalic allopregnanolone (Allo) levels. In these mice, the PTB-induced loss of righting reflex is greatly reduced. Fluoxetine (FLX)...

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Bibliografski detalji
Glavni autori: Pinna, Graziano, Costa, Erminio, Guidotti, Alessandro
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2004
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC395950/
https://ncbi.nlm.nih.gov/pubmed/15069199
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0401479101
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