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Characterization of brain neurons that express enzymes mediating neurosteroid biosynthesis

Allopregnanolone (ALLO) and tetrahydrodeoxycorticosterone (THDOC) are potent positive allosteric modulators of GABA action at GABA(A) receptors. ALLO and THDOC are synthesized in the brain from progesterone or deoxycorticosterone, respectively, by the sequential action of two enzymes: 5α-reductase (...

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Detalhes bibliográficos
Main Authors: Agís-Balboa, Roberto C., Pinna, Graziano, Zhubi, Adrian, Maloku, Ekrem, Veldic, Marin, Costa, Erminio, Guidotti, Alessandro
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1600006/
https://ncbi.nlm.nih.gov/pubmed/16984997
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0606544103
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