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Characterization of brain neurons that express enzymes mediating neurosteroid biosynthesis
Allopregnanolone (ALLO) and tetrahydrodeoxycorticosterone (THDOC) are potent positive allosteric modulators of GABA action at GABA(A) receptors. ALLO and THDOC are synthesized in the brain from progesterone or deoxycorticosterone, respectively, by the sequential action of two enzymes: 5α-reductase (...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2006
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1600006/ https://ncbi.nlm.nih.gov/pubmed/16984997 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0606544103 |
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