A chimeric adenovirus vector encoding reovirus attachment protein σ1 targets cells expressing junctional adhesion molecule 1

The utility of adenovirus (Ad) vectors for gene transduction can be limited by receptor specificity. We developed a gene-delivery vehicle in which the potent Ad5 vector was genetically reengineered to display the mucosal-targeting σ1 protein of reovirus type 3 Dearing (T3D). A σ1 construct containin...

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Detaylı Bibliyografya
Asıl Yazarlar: Mercier, George T., Campbell, Jacquelyn A., Chappell, James D., Stehle, Thilo, Dermody, Terence S., Barry, Michael A.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2004
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC395944/
https://ncbi.nlm.nih.gov/pubmed/15079060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0400542101
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