The immunomodulatory adapter proteins DAP12 and Fc receptor γ-chain (FcRγ) regulate development of functional osteoclasts through the Syk tyrosine kinase

Osteoclasts, the only bone-resorbing cells, are central to the pathogenesis of osteoporosis, yet their development and regulation are incompletely understood. Multiple receptors of the immune system use a common signaling paradigm whereby phosphorylated immunoreceptor tyrosine-based activation motif...

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Bibliographic Details
Main Authors: Mócsai, Attila, Humphrey, Mary Beth, Van Ziffle, Jessica A. G., Hu, Yongmei, Burghardt, Andrew, Spusta, Steven C., Majumdar, Sharmila, Lanier, Lewis L., Lowell, Clifford A., Nakamura, Mary C.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2004
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC395939/
https://ncbi.nlm.nih.gov/pubmed/15073337
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0401602101
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