Thiopurine methyltransferase genotype and thiopurine S-methyltransferase activity in Greek children with inflammatory bowel disease

BACKGROUND: Azathioprine (AZA) and 6-mercaptopurine (6MP) are used in the treatment of pediatric inflammatory bowel disease (IBD). Genetic variations in thiopurine S-methyltranfarase (TPMT) gene have been correlated with enzyme activity and with the occurrence of adverse events to AZA and 6MP. The a...

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Hlavní autoři: Gazouli, Μaria, Pachoula, Ioanna, Panayotou, Ioanna, Chouliaras, Georgios, Anagnou, Nicholas P., Chroussos, George, Roma, Eleftheria
Médium: Artigo
Jazyk:Inglês
Vydáno: Hellenic Society of Gastroenterology 2012
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3959370/
https://ncbi.nlm.nih.gov/pubmed/24714152
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