Mutations in the G-quadruplex silencer element and their relationship to c-MYC overexpression, NM23 repression, and therapeutic rescue

We have demonstrated that a parallel G-quadruplex structure in the c-MYC promoter functions as a transcriptional repressor element. Furthermore, a specific G-to-A mutation in this element results in destabilization of the G-quadruplex repressor element and an increase in basal transcriptional activi...

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Detalhes bibliográficos
Main Authors: Grand, Cory L., Powell, Tiffanie J., Nagle, Raymond B., Bearss, David J., Tye, Denise, Gleason-Guzman, Mary, Hurley, Laurence H.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2004
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC395936/
https://ncbi.nlm.nih.gov/pubmed/15079086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0400460101
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