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Direct evidence for a G-quadruplex in a promoter region and its targeting with a small molecule to repress c-MYC transcription
The nuclease hypersensitivity element III(1) upstream of the P1 promoter of c-MYC controls 85–90% of the transcriptional activation of this gene. We have demonstrated that the purine-rich strand of the DNA in this region can form two different intramolecular G-quadruplex structures, only one of whic...
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| Autors principals: | , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
The National Academy of Sciences
2002
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC129314/ https://ncbi.nlm.nih.gov/pubmed/12195017 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.182256799 |
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