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A DNA polymerase β mutant from colon cancer cells induces mutations

Previous investigations have shown that ≈35% of the 90 tumors analyzed to date contain mutations within the DNA polymeraseβ (pol β) gene. The existence of pol β mutations in a substantial fraction of human tumors studied suggests a link between DNA pol β and cancer. A DNA pol β variant, in which Lys...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Lang, Tieming, Maitra, Mausumi, Starcevic, Daniela, Li, Shu-Xia, Sweasy, Joann B.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2004
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC395925/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15075389/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0308571101
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