Mechanisms for activating Cu- and Zn-containing superoxide dismutase in the absence of the CCS Cu chaperone

The Cu- and Zn-containing superoxide dismutase 1 (SOD1) largely obtains Cu in vivo by means of the action of the Cu chaperone CCS. Yet, in the case of mammalian SOD1, a secondary pathway of activation is apparent. Specifically, when human SOD1 is expressed in either yeast or mammalian cells that are...

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Bibliographic Details
Main Authors: Carroll, Mark C., Girouard, Jody B., Ulloa, Janella L., Subramaniam, Jamuna R., Wong, Phillip C., Valentine, Joan Selverstone, Culotta, Valeria Cizewski
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2004
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC395906/
https://ncbi.nlm.nih.gov/pubmed/15069187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0308298101
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