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The Effects of Glutaredoxin and Copper Activation Pathways on the Disulfide and Stability of Cu,Zn Superoxide Dismutase

Mutations in Cu,Zn superoxide dismutase (SOD1) can cause amyotrophic lateral sclerosis (ALS) through mechanisms proposed to involve SOD1 misfolding, but the intracellular factors that modulate folding and stability of SOD1 are largely unknown. By using yeast and mammalian expression systems, we demo...

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書誌詳細
主要な著者: Carroll, Mark C., Outten, Caryn E., Proescher, Jody B., Rosenfeld, Leah, Watson, Walter H., Whitson, Lisa J., Hart, P. John, Jensen, Laran T., Culotta, Valeria Cizewski
フォーマット: Artigo
言語:Inglês
出版事項: 2006
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2757158/
https://ncbi.nlm.nih.gov/pubmed/16880213
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M600138200
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