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Light exposure stimulates formation of A2E oxiranes in a mouse model of Stargardt's macular degeneration
Recessive Stargardt's macular degeneration is a blinding disease of children caused by mutations in the ABCA4 (ABCR) gene. Mice with a knockout mutation in abcr accumulate toxic lipofuscin pigments in ocular tissues, similar to affected humans. The major fluorophore of lipofuscin is the bis-ret...
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| Autori principali: | , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
2004
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC395900/ https://ncbi.nlm.nih.gov/pubmed/15067110 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0308302101 |
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