Soluble Calreticulin Induces Tumor Necrosis Factor-α (TNF-α) and Interleukin (IL)-6 Production by Macrophages through Mitogen-Activated Protein Kinase (MAPK) and NFκB Signaling Pathways

We have recently reported that soluble calreticulin (CRT) accumulates in the sera of patients with rheumatoid arthritis or systemic lupus erythematosus. Moreover, following self-oligomerization, soluble recombinant CRT (rCRT) polypeptides exhibit potent immunostimulatory activities including macroph...

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Detalhes bibliográficos
Main Authors: Duo, Cui-Cui, Gong, Fang-Yuan, He, Xiao-Yan, Li, Yan-Mei, Wang, Jun, Zhang, Jin-Ping, Gao, Xiao-Ming
Formato: Artigo
Idioma:Inglês
Publicado em: Molecular Diversity Preservation International (MDPI) 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3958890/
https://ncbi.nlm.nih.gov/pubmed/24566135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms15022916
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