Prolonged Calcitonin Receptor Signaling by Salmon, but Not Human Calcitonin, Reveals Ligand Bias

Salmon calcitonin (sCT) and human calcitonin (hCT) are pharmacologically distinct. However, the reason for the differences is unclear. Here we analyze the differences between sCT and hCT on the human calcitonin receptor (CT((a))R) with respect to activation of cAMP signaling, β-arrestin recruitment,...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Andreassen, Kim Vietz, Hjuler, Sara Toftegaard, Furness, Sebastian G., Sexton, Patrick M., Christopoulos, Arthur, Nosjean, Olivier, Karsdal, Morten Asser, Henriksen, Kim
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2014
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3958426/
https://ncbi.nlm.nih.gov/pubmed/24643196
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0092042
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