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Enhanced Virulence of Sheep-Passaged Bovine Spongiform Encephalopathy Agent Is Revealed by Decreased Polymorphism Barriers in Prion Protein Conversion Studies

Bovine spongiform encephalopathy (BSE) can be efficiently transmitted to small ruminants (sheep and goats) with certain prion protein (PrP) genotypes. Polymorphisms in PrP of both the host and donor influence the transmission efficiency of transmissible spongiform encephalopathies (TSEs) in general....

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Detalhes bibliográficos
Main Authors: Priem, Jan, Langeveld, Jan P. M., van Keulen, Lucien J. M., van Zijderveld, Fred G., Andreoletti, Olivier, Bossers, Alex
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3958111/
https://ncbi.nlm.nih.gov/pubmed/24371051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02446-13
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