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An Increase in Acid Resistance of Foot-and-Mouth Disease Virus Capsid Is Mediated by a Tyrosine Replacement of the VP2 Histidine Previously Associated with VP0 Cleavage

The foot-and-mouth disease virus (FMDV) capsid is highly acid labile, but introduction of amino acid replacements, including an N17D change in VP1, can increase its acid resistance. Using mutant VP1 N17D as a starting point, we isolated a virus with higher acid resistance carrying an additional repl...

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Bibliographische Detailangaben
Hauptverfasser: Vázquez-Calvo, Angela, Caridi, Flavia, Sobrino, Francisco, Martín-Acebes, Miguel A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2014
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3958075/
https://ncbi.nlm.nih.gov/pubmed/24352460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.03222-13
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