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Specific Residues of PB2 and PA Influenza Virus Polymerase Subunits Confer the Ability for RNA Polymerase II Degradation and Virus Pathogenicity in Mice

Influenza virus transcription requires functional coupling with cellular transcription for the cap-snatching process. Despite this fact, RNA polymerase II (RNAP II) is degraded during infection in a process triggered by the viral polymerase. Reassortant viruses from the A/PR/8/34 (PR8) strain that i...

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Detalhes bibliográficos
Main Authors: Llompart, C. M., Nieto, A., Rodriguez-Frandsen, A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3957926/
https://ncbi.nlm.nih.gov/pubmed/24403580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02263-13
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