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Antibiotic Streptolydigin Requires Noncatalytic Mg(2+) for Binding to RNA Polymerase
Multisubunit RNA polymerase, an enzyme that accomplishes transcription in all living organisms, is a potent target for antibiotics. The antibiotic streptolydigin inhibits RNA polymerase by sequestering the active center in a catalytically inactive conformation. Here, we show that binding of streptol...
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| 主要な著者: | , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Society for Microbiology
2014
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3957892/ https://ncbi.nlm.nih.gov/pubmed/24342645 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02248-13 |
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