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Anti-Platelet Therapy with Clopidogrel Prevents Endothelial Dysfunction and Vascular Remodeling in Aortas from Hypertensive Rats

The aim was to investigate the beneficial effects of clopidogrel in thoracic aorta function and structure and to characterize if P2Y(12) receptors contribute to these effects. Male Sprague Dawley rats were infused with angiotensin II [(Ang II) 60 ng.min(−1), 14 days] or saline (control rats) and wer...

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Dettagli Bibliografici
Autori principali: Giachini, Fernanda R., Leite, Romulo, Osmond, David A., Lima, Victor V., Inscho, Edward W., Webb, R. Clinton, Tostes, Rita C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3956760/
https://ncbi.nlm.nih.gov/pubmed/24638017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0091890
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