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Clopidogrel, independent of vascular P2Y(12) receptor, improves the arterial function in small mesenteric arteries from Ang II-hypertensive rats

The P2Y(12) receptor antagonist clopidogrel blocks platelet aggregation, improves systemic endothelial nitric oxide bioavailability, and has anti-inflammatory effects. Since P2Y(12) receptors have been identified in the vasculature, we hypothesized that clopidogrel ameliorates angiotensin II (Ang II...

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Detalhes bibliográficos
Main Authors: Giachini, Fernanda R.C., Osmond, David A., Zhang, Shali, Carneiro, Fernando S., Lima, Victor V., Inscho, Edward W., Webb, R. Clinton, Tostes, Rita C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3061981/
https://ncbi.nlm.nih.gov/pubmed/19811450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/CS20090392
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