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Design of an Amide N-glycoside Derivative of β-Glucogallin: A Stable, Potent, and Specific Inhibitor of Aldose Reductase

β-glucogallin (BGG), a major component of the Emblica officinalis medicinal plant, is a potent and selective inhibitor of aldose-reductase (AKR1B1). New linkages (ether/triazole/amide) were introduced via high yielding, efficient syntheses to replace the labile ester, and an original 2-step (90%) pr...

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Bibliografiske detaljer
Main Authors: Li, Linfeng, Chang, Kun-Che, Zhou, Yaming, Shieh, Biehuoy, Ponder, Jessica, Abraham, Adedoyin D., Ali, Hadi, Snow, Anson, Petrash, J. Mark, LaBarbera, Daniel V.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3956592/
https://ncbi.nlm.nih.gov/pubmed/24341381
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm401311d
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