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Inhibition of Patched-1 Prevents Injury-induced Neointimal Hyperplasia

OBJECTIVE: To determine the role of Ptc-1 in mediating pulsatile flow-induced changes in VSMC growth and vascular remodeling. APPROACH AND RESULTS: In vitro, HCASMC were exposed to “normal” or pathological “low” pulsatile flow conditions for 24 h utilizing a perfused transcapillary flow system. Low...

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Autors principals: Redmond, Eileen M, Hamm, Katie, Cullen, John P, Hatch, Ekaterina, Cahill, Paul A, Morrow, David
Format: Artigo
Idioma:Inglês
Publicat: 2013
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3956445/
https://ncbi.nlm.nih.gov/pubmed/23766265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.113.301843
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