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Phase II trial of patupilone in patients with brain metastases from breast cancer

BACKGROUND: For patients with progressive breast cancer brain metastasis (BCBM) after whole brain radiotherapy (WBRT), few options exist. Patupilone is an epothilone that crosses the blood–brain barrier. We hypothesized that patupilone would produce a 35% 3-month CNS progression-free survival in wom...

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Main Authors: Peereboom, David M., Murphy, Conleth, Ahluwalia, Manmeet S., Conlin, Alison, Eichler, April, Van Poznak, Catherine, Baar, Joseph, Elson, Paul, Seidman, Andrew D.
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2014
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3956359/
https://ncbi.nlm.nih.gov/pubmed/24470546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/not305
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