Selective treatment and monitoring of disseminated cancer micrometastases in vivo using dual-function, activatable immunoconjugates

Drug-resistant micrometastases that escape standard therapies often go undetected until the emergence of lethal recurrent disease. Here, we show that it is possible to treat microscopic tumors selectively using an activatable immunoconjugate. The immunoconjugate is composed of self-quenching, near-i...

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Detalhes bibliográficos
Main Authors: Spring, Bryan Q., Abu-Yousif, Adnan O., Palanisami, Akilan, Rizvi, Imran, Zheng, Xiang, Mai, Zhiming, Anbil, Sriram, Sears, R. Bryan, Mensah, Lawrence B., Goldschmidt, Ruth, Erdem, S. Sibel, Oliva, Esther, Hasan, Tayyaba
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3956156/
https://ncbi.nlm.nih.gov/pubmed/24572574
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1319493111
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