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Chiral Effect of a Phe Residue in Position 3 of the Dmt(1)-l(or d)-Tic(2) Analogues on Opioid Functional Activities

[Image: see text] In this letter, we describe a structure–activity relationships study, specifically related to the chirality of third amino acid residue in our H-Dmt-l(or d)-Tic analogues, of which C-terminus is attached to a piperidinyl moiety. Observed selectivities and functional activities of t...

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Detalhes bibliográficos
Main Authors: Lee, Yeon Sun, Qu, HongChang, Davis, Peg, Ma, Shou-Wu, Vardanyan, Ruben, Lai, Josephine, Porreca, Frank, Hruby, Victor J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2013
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3956057/
https://ncbi.nlm.nih.gov/pubmed/24648867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml400115n
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