Resistance of K-RasBV12 proteins to farnesyltransferase inhibitors in Rat1 cells.
Benzodiazepine (BZA)-5B, a CAAX farnesyl-transferase inhibitor, was previously shown to block the farnesylation of H-Ras and to reverse the transformed morphology of Rat1 cells expressing oncogenic H-RasV12. Non-transformed Rat1 cells were not affected by BZA-5B, suggesting that they produce a form...
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| Publicat a: | Proc Natl Acad Sci U S A |
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| Autors principals: | , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
1996
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC39559/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8633088/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.9.4454 |
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