p53 oligomerization and DNA looping are linked with transcriptional activation.

We examined the role of p53 oligomerization in DNA binding and in transactivation. By conventional electron microscopy (EM) and scanning transmission EM, we find that wild-type tetramers contact 18-20 bp at single or tandem 19 bp consensus sequences and also stack in apparent register, tetramer on t...

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Main Authors: Stenger, J E, Tegtmeyer, P, Mayr, G A, Reed, M, Wang, Y, Wang, P, Hough, P V, Mastrangelo, I A
Format: Artigo
Sprog:Inglês
Udgivet: 1994
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC395578/
https://ncbi.nlm.nih.gov/pubmed/7813439
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