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Oligomerization of BAK by p53 Utilizes Conserved Residues of the p53 DNA Binding Domain

Genotoxic stress triggers a rapid translocation of p53 to the mitochondria, contributing to apoptosis in a transcription-independent manner. Using immunopurification protocols and mass spectrometry, we previously identified the proapoptotic protein BAK as a mitochondrial p53-binding protein and show...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Pietsch, E. Christine, Perchiniak, Erin, Canutescu, Adrian A., Wang, Guoli, Dunbrack, Roland L., Murphy, Maureen E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2008
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2475706/
https://ncbi.nlm.nih.gov/pubmed/18524770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M710539200
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