Oligomerization of BAK by p53 Utilizes Conserved Residues of the p53 DNA Binding Domain

Genotoxic stress triggers a rapid translocation of p53 to the mitochondria, contributing to apoptosis in a transcription-independent manner. Using immunopurification protocols and mass spectrometry, we previously identified the proapoptotic protein BAK as a mitochondrial p53-binding protein and show...

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Bibliografiska uppgifter
Huvudupphovsmän: Pietsch, E. Christine, Perchiniak, Erin, Canutescu, Adrian A., Wang, Guoli, Dunbrack, Roland L., Murphy, Maureen E.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2008
Ämnen:
Mechanisms of Signal Transduction
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2475706/
https://ncbi.nlm.nih.gov/pubmed/18524770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M710539200
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