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Association of Immunosuppressant-induced Protein Changes in the Rat Kidney with Changes in Urine Metabolite Patterns: A Proteo-Metabonomic Study

The basic mechanisms underlying calcineurin inhibitor (CI) nephrotoxicity and its enhancement by sirolimus are still largely unknown. We investigated the effects of CIs alone and in combination with sirolimus on the renal proteome and correlated these effects with urine metabolite pattern changes. T...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Klawitter, Jost, Klawitter, Jelena, Kushner, Erich, Jonscher, Karen, Bendrick-Peart, Jamie, Leibfritz, Dieter, Christians, Uwe, Schmitz, Volker
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3955702/
https://ncbi.nlm.nih.gov/pubmed/19994912
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/pr900761m
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