Class I HDACs are mediators of smoke-carcinogen induced stabilization of DNMT1 and serve as promising targets for chemoprevention of lung cancer

DNA methylation is an early event in bronchial carcinogenesis and increased DNA methyltransferase (DNMT)1 protein expression is a crucial step in the oncogenic transformation of epithelia. Here, we investigate the role of class I histone deacetylases (HDACs) 1–3 in the stabilization of DNMT1 protein...

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Bibliographic Details
Main Authors: Brodie, Seth A, Li, Ge, El-Kommos, Adam, Kang, Hyunseok, Ramalingam, Suresh S, Behera, Madhusmita, Gandhi, Khanjan, Kowalski, Jeanne, Sica, Gabriel L, Khuri, Fadlo R, Vertino, Paula M., Brandes, Johann C
Format: Artigo
Language:Inglês
Published: 2014
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3955098/
https://ncbi.nlm.nih.gov/pubmed/24441677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1940-6207.CAPR-13-0254
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