Class I HDACs are mediators of smoke-carcinogen induced stabilization of DNMT1 and serve as promising targets for chemoprevention of lung cancer

DNA methylation is an early event in bronchial carcinogenesis and increased DNA methyltransferase (DNMT)1 protein expression is a crucial step in the oncogenic transformation of epithelia. Here, we investigate the role of class I histone deacetylases (HDACs) 1–3 in the stabilization of DNMT1 protein...

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Detalhes bibliográficos
Main Authors: Brodie, Seth A, Li, Ge, El-Kommos, Adam, Kang, Hyunseok, Ramalingam, Suresh S, Behera, Madhusmita, Gandhi, Khanjan, Kowalski, Jeanne, Sica, Gabriel L, Khuri, Fadlo R, Vertino, Paula M., Brandes, Johann C
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3955098/
https://ncbi.nlm.nih.gov/pubmed/24441677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1940-6207.CAPR-13-0254
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