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HOW IMMUNE PEPTIDASES CHANGE SPECIFICITY: Cathepsin G Gained Tryptic Function but Lost Efficiency during Primate Evolution()
Cathepsin G is a major secreted serine peptidase of neutrophils and mast cells. Studies in Ctsg-null mice suggest that cathepsin G supports antimicrobial defenses but can injure host tissues. The human enzyme has unusual “Janus-faced” ability to cleave peptides at basic (tryptic) as well as aromatic...
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| 主要な著者: | , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2010
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3954857/ https://ncbi.nlm.nih.gov/pubmed/20889553 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1002292 |
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