p40MO15 associates with a p36 subunit and requires both nuclear translocation and Thr176 phosphorylation to generate cdk-activating kinase activity in Xenopus oocytes.

p40MO15, a cdc2-related protein, is the catalytic subunit of the kinase (CAK, cdk-activating kinase) responsible for Thr161/Thr160 phosphorylation and activation of cdk1/cdk2. We have found that strong overexpression of p40MO15 only moderately increases CAK activity in Xenopus oocytes, indicating th...

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Detalles Bibliográficos
Publicado en:EMBO J
Main Authors: Labbé, J C, Martinez, A M, Fesquet, D, Capony, J P, Darbon, J M, Derancourt, J, Devault, A, Morin, N, Cavadore, J C, Dorée, M
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 1994
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC395463/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7957080/
https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1994.tb06845.x
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