p40MO15 associates with a p36 subunit and requires both nuclear translocation and Thr176 phosphorylation to generate cdk-activating kinase activity in Xenopus oocytes.

p40MO15, a cdc2-related protein, is the catalytic subunit of the kinase (CAK, cdk-activating kinase) responsible for Thr161/Thr160 phosphorylation and activation of cdk1/cdk2. We have found that strong overexpression of p40MO15 only moderately increases CAK activity in Xenopus oocytes, indicating th...

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Vydáno v:	EMBO J
Hlavní autoři:	Labbé, J C, Martinez, A M, Fesquet, D, Capony, J P, Darbon, J M, Derancourt, J, Devault, A, Morin, N, Cavadore, J C, Dorée, M
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Nature Publishing Group 1994
Témata:	Research Article
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC395463/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7957080/ https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1994.tb06845.x
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p40MO15 associates with a p36 subunit and requires both nuclear translocation and Thr176 phosphorylation to generate cdk-activating kinase activity in Xenopus oocytes.

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