SIK2 is a centrosome kinase required for bipolar mitotic spindle formation that provides a potential target for therapy in ovarian cancer

Regulators of mitosis have been successfully targeted to enhance response to taxane chemotherapy. Here, we show that the Salt Inducible Kinase 2 (SIK2) localizes at the centrosome, plays a key role in the initiation of mitosis and regulates the localization of the centrosome linker protein, C-Nap1,...

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Hauptverfasser: Ashour Ahmed, Ahmed, Lu, Zhen, Jennings, Nicholas B, Etemadmoghadam, Dariush, Capalbo, Luisa, Jacamo, Rodrigo O., Barbosa-Morais, Nuno, Le, Xiao-Feng, Vivas-Mejia, Pablo, Lopez-Berestein, Gabriel, Grandjean, Geoffrey, Bartholomeusz, Geoffrey, Liao, Warren, Andreeff, Michael, Bowtell, David, Glover, David M, Sood, Anil K, Bast, Robert C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3954541/
https://ncbi.nlm.nih.gov/pubmed/20708153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2010.06.018
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