AKAP150 Contributes to Enhanced Vascular Tone by Facilitating BK(Ca) Channel Remodeling in Hyperglycemia and Diabetes

RATIONALE: Increased contractility of arterial myocytes and enhanced vascular tone during hyperglycemia and diabetes may arise from impaired large conductance Ca(2+)-activated K(+) (BK(Ca)) channel function. The scaffolding protein AKAP150 is a key regulator of calcineurin (CaN), a phosphatase known...

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Hauptverfasser: Nystoriak, Matthew A., Nieves-Cintrón, Madeline, Nygren, Patrick J., Hinke, Simon A., Nichols, C. Blake, Chen, Chao-Yin, Puglisi, Jose L., Izu, Leighton T., Bers, Donald M., Dell’Acqua, Mark L., Scott, John D., Santana, Luis F., Navedo, Manuel F.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3954117/
https://ncbi.nlm.nih.gov/pubmed/24323672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.114.302168
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