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Genistein reverses hypermethylation and induces active histone modifications in tumor suppressor gene B-cell Translocation Gene 3 (BTG3) in prostate cancer
BACKGROUND: BTG3/ANA/APRO4 is a candidate tumor suppressor gene in some malignancies. We report here that BTG3 is transcriptionally down-regulated in prostate cancer and the mechanism of inactivation is through promoter hypermethylation. METHODS: Prostate cancer and normal cell lines were treated wi...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3954042/ https://ncbi.nlm.nih.gov/pubmed/19885928 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cncr.24662 |
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