Human and Non-Human Primate Intestinal FcRn Expression and Immunoglobulin G Transcytosis

PURPOSE: To evaluate transcytosis of immunoglobulin G (IgG) by the neonatal Fc receptor (FcRn) in adult primate intestine to determine whether this is a means for oral delivery of monoclonal antibodies (mAbs). METHODS: Relative regional expression of FcRn and localization in human intestinal mucosa...

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Autors principals: Hornby, Pamela J., Cooper, Philip R., Kliwinski, Connie, Ragwan, Edwin, Mabus, John R., Harman, Benjamin, Thompson, Suzanne, Kauffman, Amanda L., Yan, Zhengyin, Tam, Susan H., Dorai, Haimanti, Powers, Gordon D., Giles-Komar, Jill
Format: Artigo
Idioma:Inglês
Publicat: Springer US 2013
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3953555/
https://ncbi.nlm.nih.gov/pubmed/24072267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-013-1212-3
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