Claudin-3 and Claudin-5 Protein Folding and Assembly into the Tight Junction Are Controlled by Non-conserved Residues in the Transmembrane 3 (TM3) and Extracellular Loop 2 (ECL2) Segments

The mechanism of tight junction (TJ) assembly and the structure of claudins (Cldn) that form the TJ strands are unclear. This limits the molecular understanding of paracellular barriers and strategies for drug delivery across tissue barriers. Cldn3 and Cldn5 are both common in the blood-brain barrie...

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Detalhes bibliográficos
Main Authors: Rossa, Jan, Ploeger, Carolin, Vorreiter, Fränze, Saleh, Tarek, Protze, Jonas, Günzel, Dorothee, Wolburg, Hartwig, Krause, Gerd, Piontek, Jörg
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3953276/
https://ncbi.nlm.nih.gov/pubmed/24478310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.531012
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